What Is Semaglutide?
Semaglutide is a GLP-1 receptor agonist — a once-weekly injectable medication that mimics a natural gut hormone your body releases after eating. It reduces appetite, slows stomach emptying, and helps you feel satisfied with smaller meals, making sustainable weight loss achievable where willpower alone has failed. It is offered at our Bryn Mawr practice as part of our physician-supervised Medical Weight Loss Program with Dr. Joseph Castelli.
How Does GLP-1 Weight Loss Work?
GLP-1 (glucagon-like peptide-1) is one of the hormones that tells your brain you are full. Semaglutide amplifies that signal: hunger quiets, portion sizes shrink naturally, and cravings lose their grip — while the medication also improves how your body handles blood sugar. Doses start low and increase gradually over several weeks to minimize side effects; see our semaglutide dosage chart guide for how titration works.
What Results Can I Expect?
In the largest clinical trials, adults using weekly semaglutide alongside lifestyle changes lost roughly 15% of their body weight on average over 68 weeks — several times more than lifestyle changes alone. Individual results vary, which is why your dose, progress, and plan are reviewed with Dr. Castelli at regular follow-ups.
Semaglutide Or Tirzepatide?
Semaglutide activates one hormone pathway (GLP-1); tirzepatide activates two (GLP-1 and GIP) and produced greater average weight loss in trials. Semaglutide has the longer track record and is often the right starting point. Candidacy, cost, and your medical history all factor in — Dr. Castelli will recommend the better fit at your evaluation.
Schedule A Semaglutide Consultation
Find out if GLP-1 therapy is right for you. Call 610-789-6701 or request an appointment online to schedule your medical evaluation with Dr. Castelli in Bryn Mawr, PA.
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Semaglutide FAQ’S
Can I get semaglutide in Bryn Mawr, PA?
Yes — semaglutide is prescribed through the physician-supervised Medical Weight Loss Program at Lux Skin & Lasers in Bryn Mawr, PA, led by Dr. Joseph Castelli and serving the Main Line and greater Philadelphia.
How is semaglutide taken?
As a small once-weekly injection with a very fine needle, typically self-administered at home after your first guided dose. Your dose starts low and steps up gradually over several weeks.
What are the most common side effects?
Mild nausea, constipation, or digestive upset during dose increases are most common and usually fade as your body adjusts. Gradual titration and physician monitoring keep side effects manageable.
How fast will I see results?
Most patients notice reduced appetite within the first weeks and measurable weight loss within the first one to two months, with results building steadily over the following months as the dose reaches its maintenance level.
Do I have to stay on semaglutide forever?
Not necessarily. Weight regain is possible after stopping, so Dr. Castelli builds a maintenance strategy — lifestyle foundations, tapering, or a maintenance dose — into your plan from the start.
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